HUMANIZED SUBSTITUTIONS OF VMAT1 IN MICE ALTER AMYGDALA-DEPENDENT BEHAVIORS ASSOCIATED WITH THE EVOLUTION OF ANXIETY

Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles.These substitutions plastic jigger are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emoti

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Geological characteristics and models of fault-fold-fracture body in deep tight sandstone of the second member of Upper Triassic Xujiahe Formation in Xinchang structural belt of Sichuan Basin, SW China

In the second member of the Upper Triassic Xujiahe Formation (T3x2) in the Xinchang area, western Sichuan Basin, only a low percent of reserves has been recovered, and the geological model of gas reservoir sweet spot remains unclear.Based on a large number of core, field outcrop, test and logging-seismic data, the T3x2 gas reservoir in the Xinchang

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A Bayesian Belief Network for Local Air Quality Forecasting

This study is focused on the development of a Bayesian network for air quality assessment and aims at offering a pragmatic and scientifically credible approach to modelling complex systems where substantial uncertainties exist.In black knight darts particular, the main object is the prediction of the occurrence of suitable conditions for the stagna

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Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

Abstract Background Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic teal horse blanket asthma.Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high affinity receptor for prostaglandin D2, mediates trafficking of TH2-cells, mast cells, and eosinophi

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